Need glucose to sprout: local metabolic control of angiogenesis

Need glucose to sprout: local metabolic control of angiogenesis

Much of the focus of research in angiogenesis has been on the molecular mechanisms regulating various critical endothelial cell processes such as migration, proliferation and capillary sprouting. This has led to a number of insights including the key roles played by VEGF signalling in initiating angiogenesis (Chung & Ferrara, 2011; Koch & Claesson‐Welsh, 2012) and Notch signalling in regulating...

Modelling Tumor-induced Angiogenesis: Combination of Stochastic Sprout Spacing and Sprout Progression

Background: Angiogenesis initiated by cancerous cells is the process by which new blood vessels are formed to enhance oxygenation and growth of tumor. Objective: In this paper, we present a new multiscale mathematical model for the formation of a vascular network in tumor angiogenesis process. Methods: Our model couples an improved sprout spacing model as a stochastic mathematical model of spro...

Modelling Tumor-induced Angiogenesis: Combination of Stochastic Sprout Spacing and Sprout Progression

BACKGROUND Angiogenesis initiated by cancerous cells is the process by which new blood vessels are formed to enhance oxygenation and growth of tumor. OBJECTIVE In this paper, we present a new multiscale mathematical model for the formation of a vascular network in tumor angiogenesis process. METHODS Our model couples an improved sprout spacing model as a stochastic mathematical model of spr...

Chemical Sprout Control of Alaskan Potatoes

Metabolic cycling in control of glucose-stimulated insulin secretion.

Glucose-stimulated insulin secretion (GSIS) is central to normal control of metabolic fuel homeostasis, and its impairment is a key element of beta-cell failure in type 2 diabetes. Glucose exerts its effects on insulin secretion via its metabolism in beta-cells to generate stimulus/secretion coupling factors, including a rise in the ATP/ADP ratio, which serves to suppress ATP-sensitive K(+) (K(...